FPDc

Actual value (ms)

% of Pre

Concentration (μM)

n

Pre

10 min

4 h

24 h

Pre

10 min

4 h

24 h

Vehicle

4

276.7 ± 7.6

278.0 ± 6.4

277.3 ± 5.8

286.2 ± 12.6

100

100.6 ± 2.9

100.5 ± 3.6

103.8 ± 6.0

0.1

3

317.4 ± 44.1

316.7 ± 41.5

310.7 ± 42.2

333.6 ± 37.8

100

100.0 ± 0.8

98.0 ± 1.3

105.9 ± 3.1

0.3

4

347.5 ± 25.8

348.5 ± 26.2

354.4 ± 26.9

389.6 ± 34.5^*

100

100.3 ± 0.9

102.0 ± 0.9

111.8 ± 2.8^*

1

4

270.8 ± 34.4

272.0 ± 34.5

273.0 ± 33.0

299.3 ± 41.3^*

100

100.5 ± 0.4

101.1 ± 1.2

110.0 ± 2.2^*

3

3

367.3 ± 18.4

370.8 ± 17.1

382.7 ± 20.9^*

396.8 ± 19.5^**

100

101.0 ± 0.5

104.2 ± 0.6^*

108.1 ± 0.6^**

10

3

278.7 ± 37.7

275.6 ± 35.6

287.2 ± 38.2^**

322.8 ± 40.0^*

100

99.1 ± 0.7

103.1 ± 0.3^**

116.2 ± 2.5^*